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Gene therapy enables five children who were born deaf to hear

Five children have had gene therapy to treat inherited deafness, this time in both ears, following the success of earlier treatments in just one ear

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The therapy makes cuts in the gene for kallikrein (shown as graphics), a protein involved in inflammation

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CRISPR gene therapy seems to cure dangerous inflammatory condition

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The reward pathway in the brain, which is initiated in response to a stimulus, such as alcohol. The stimulus (upper orange arrow) triggers the release of dopamine (blue arrows) by the ventral tegmental area (dark blue sphere). The dopamine travels to a number of different areas of the brain that then release dopamine (red arrows). These areas include the nucleus accumbens (red sphere), which initiates motor outputs (lower orange arrow) to sustain the pleasurable stimulus, the prefrontal cortex (pink), which shifts focus and planning towards the stimulus, and the amygdala, which is involved in emotions. The hypothalamus (orange sphere) is involved in coordinating the response by secreting hormones that control bodily functions

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Gene therapy delivered into the brain could treat alcohol misuse

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Targeted mRNA delivery will lead to cheaper cures for many diseases

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Targeted mRNA delivery will lead to cheaper cures for many diseases

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People with total colour blindness able to see red after gene therapy

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How CRISPR therapy could cure everything from cancer to infertility

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How CRISPR therapy could cure everything from cancer to infertility

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Model of bacteriophage T4

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Virus that carries huge amounts of DNA could advance gene therapies

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A scanning electron micrograph of a brown fat cell surrounded by capillaries

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Surrounding tumours with brown fat could starve them of nutrients

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DNA

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Gene-replacement therapies are transforming children’s lives

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Artemis-deficient SCID

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Gene therapy restored immune system in children with rare disorder

Ten children with the rare condition Artemis-deficient severe combined immunodeficiency had their immune systems either partially or fully restored with gene-replacement therapy

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Gene therapy infused into the brain eases rare condition in children

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Radical lupus treatment uses CAR T-cell therapy developed for cancer

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Gene therapy trial shows early success in people with haemophilia B

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Gene-replacement therapy is helping children overcome fatal diseases

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